Cart (Loading....) | Create Account
Close category search window
 

Energy Absorption of Gold Nanoshells in Hyperthermia Therapy

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Changhong Liu ; Shanghai Jiao Tong Univ., Shanghai ; Mi, C.C. ; Li, B.Q.

The unique optical characteristics of a gold nanoshell motivate the application of nanoshell-based hyperthermia in drug delivery and cancer treatment. However, most of our understanding on energy absorption and heat transfer is still focused on individual particles, which may not be accurate for nanoshell aggregates in a real application due to the strong optical interaction of nanoshells. This paper investigates the relationship between the optical interaction and the interparticle distance in the visible and near-infrared regions by means of a finite-difference time-domain (FDTD) method. The objective is to explore the energy transportation mechanism, which is critical for hyperthermia therapy. From the numerical simulation results of different forms of nanoshell aggregates, including individual nanoshells, 1-D chains, 2-D arrays, and 3-D clusters, it was found that the interparticle distance plays a crucial role from the maximal absorption point of view. The interparticle distance affects both field enhancement and surface plasmon resonance position. The accurate prediction of energy absorption also helps the way nanoshells are populated in the tumor cell so as to prevent heat damage to healthy tissues in clinic applications. In the case of 3-D clusters, the laser energy decays exponentially along the wave propagation, and the penetration depth greatly depends on the interparticle distance. The closer the nanoshells are placed, the shorter the penetration depth is. The maximal total length for the laser penetration through the shell of gold nanoparticles is about a few hundred to several nanometers. The actual penetration depth primarily depends not only on the interparticle distance, but also on the size of the nanoshells as well as other factors. Since the absorption energy is concentrated on the surface clusters of nanoparticles, heat transfer mechanisms in metal-nanoparticles-based hyperthermia will differ from that in other hyperthermia. The information obta- - ined from this paper will serve as a basis for further study of heat transfer in metal-nanoparticles-based hyperthermia.

Published in:

NanoBioscience, IEEE Transactions on  (Volume:7 ,  Issue: 3 )

Date of Publication:

Sept. 2008

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.