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A distributed and integrated framework for missile design and manufacturing is developed in this study, using multidisciplinary optimization and workflow technology. The framework contains technologies of application integration, information integration and process integration. It can reduce the complexity of data exchange among disciplines, shorten the product development cycle and cut down the cost in product development. Users can customize system composing, design flow and data connection. In addition, the platform support engineers of optimization design and distributed design to work together. An example in this paper shows that the framework has been tested in missile design.