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With the rapid development of mixed-signal system-on-chip (SOC), the verification before tape-out is a critical phase during the design flow in order to guarantee the products yield. A design flow based on mixed-signal verification is proposed. Exemplified with the design of a mixed MCU (MV06), this paper proposes the verification precept and introduces the simulation principle and method of mixed signals in the synopsys simulation environment, and then describes the simulation process with the discovery AMS and presents the verification result. This methodology is implemented in our tape-out, the feasibility and efficiency of the method has been verified.