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Inferring the Function of Genes from Synthetic Lethal Mutations

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2 Author(s)
Oliver Ray ; Dept. of Comput. Sci., Univ. of Bristol, Bristol ; Christopher H. Bryant

Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways with a shared function. This paper introduces a logic-based approach that uses synthetic lethal mutations for mapping genes of unknown function to enzymes in a known metabolic network. We show how such mappings can be automatically computed by a logical learning system called extended hybrid abductive inductive learning (XHAIL).

Published in:

Complex, Intelligent and Software Intensive Systems, 2008. CISIS 2008. International Conference on

Date of Conference:

4-7 March 2008