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The 21st century is a quality century. How to provide the high quality production for achieving the satisfaction of customers is the target of any enterprise. Along with the advancement of science and technology, the continuous improvement in quality has been made possible by the use of computer technology and advanced quality theory. The structure of quality management system is discussed in this paper, and how to scientifically and precisely manage and analyze the production quality is also discussed in this paper. This paper also gives the functional modules of quality management decision support system under the environment of CIM. Meanwhile, this paper studies statistical process control (SPC) technology and implements the combination of SPC and ERP according to an enterprise practice. Finally, this paper gives an example to illustrate by using C++ Builder6.0 program and SQL Server2000 database. And this system realizes the reasonable, effective and methodic management of quality data in favor of the statistical analysis of quality data.