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In the 21st century, the mainstream of technology development is the interdisciplinary integration, together with the human-centered technologies (HT) that emphasizes on friendly service for human rather than the forced adaptation by human. Intelligent transportation systems (ITS), an integrated discipline of sensing, controls, information technology, electronics, communications and traffic management with transportation systems, represents a typical human-centered large-scale and highly complex dynamic system. It is aimed to provide the traveler information to increase safety, efficiency, and reduce traffic jam, therefore a more humanistic transportation system. Accordingly, new research topics emerge. Specifically, increasing machine intelligence (machine IQ), human-in-the-loop control system technology (human-centered control), human-based intelligent dialogue interface technology (human-based interfacing), vision and communication supported and enhancement systems (smart vision, smart networking), human physical conditions detection and intelligent control technology (intelligent control), multi-agent for large-scale systems to support information analysis (large-scale system analysis). This paper discusses some achievements of HT-ITS in Taiwan, including ITS information and communication platform, traffic dynamics simulation platform, driving safety assistance systems, and intelligent control technologies applied to next generation smart vehicles. Some experimental demonstrations of advanced traveler information systems (ATIS) and advanced vehicle control and safety systems (AVCSS) on Taiwan iTS-1 are also included.