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We propose injection-locked clocking (ILC) to combat deteriorating clock skew and jitter, and reduce power consumption in high-performance microprocessors. In the new clocking scheme, injection-locked oscillators are used as local clock receivers. Compared to conventional clocking with buffered trees or grids, ILC can achieve better power efficiency, lower jitter, and much simpler skew compensation thanks to its built-in deskewing capability. Unlike other alternatives, ILC is fully compatible with conventional clock distribution networks. In this paper, a quantitative study based on circuit and microarchitectural-level simulations is performed. Alpha21264 is used as the baseline processor, and is scaled to 0.13 m and 3 GHz. Simulations show 20- and 23-ps jitter reduction, 10.1% and 17% power savings in two ILC configurations. A test chip distributing 5-GHz clock is implemented in a standard 0.18- m CMOS technology and achieved excellent jitter performance and a deskew range up to 80 ps.