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Application of nanobiotechnology to construct a piezoelectric sensor matrix sensing the flexibility of immunoglobulin

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3 Author(s)
Huang, G.S. ; Instititute of Nanotechnol., Nat. Chiao Tung Univ., Hsinchu ; Yu-Shiun Chen ; Xin-Yau Lin

We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

Published in:

Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on

Date of Conference:

2-5 Aug. 2007