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Different modern information and communication technologies are emerging in all segments of our lives. The simplicity of using these high-tech and high-performance components enables us to build a wide range of enhanced and fast-in-reaction telemedical systems with the purpose of improving the quality of living. While building these systems it is easy to overlook or underestimate the need for data security and privacy protection. Telemedicine and e-health laws, regulations and standards, along with other telemedicine infrastructure components in the USA, Europe and Croatia are compared and discussed in this paper. After the common model for integrated mobile telemedical system is proposed with the example of heart-work monitoring system, all possible vulnerable and weak points in its architecture are identified and recommendations on design and implementation of similar systems are also discussed and given.