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On-Chip Fluorescence Detection Using Organic Thin Film Devices for a Disposable Lab-on-a-Chip

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4 Author(s)
Yun Shuai ; Dept. of Electr. & Comput. Eng., Univ. of Cincinnati, Cincinnati, OH ; Banerjee, A. ; Klotzkin, D. ; Papautsky, I.

In this paper, we present a high-sensitivity approach for on-chip fluorescence-based measurements for disposable lab-on-a-chip (LOC) with an integrated organic light-emitting diode (OLED) excitation source and organic photodiode (OPD) detector. A simple and inexpensive cross- polarization scheme was used to filter out excitation light from the fluorescent dye emission spectrum. We incorporated a bi- layer OPD detector with responsivity 10 times higher than conventional single heterojunction OPD, resulting in a detection limit of 1 nM, which is a 1,000-fold improvement over previous publications. The dynamic experiment was conducted and the result shows promising application in realtime fluorescence analysis. The demonstrated on-chip fluorescence detection approach is ideally suited for integration with disposable LOC devices for point-of-care diagnostics and on-site environmental testing.

Published in:

University/Government/Industry Micro/Nano Symposium, 2008. UGIM 2008. 17th Biennial

Date of Conference:

13-16 July 2008

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