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High-throughput protein binding end-points and kinetics in microarrays using label-free OI-RD microscopes

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5 Author(s)
Landry, J.P. ; Dept. of Phys., Univ. of California at Davis, Davis, CA ; Sun, Y.S. ; Fei, Y.Y. ; Lam, K.S.
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The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.

Published in:

Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on

Date of Conference:

4-9 May 2008