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Ambulatory monitoring tools provide a means for continuous assessment of patients compared to hospital based tools. Continuous physiological information such as ECG, heart rate, activity profile and energy expenditure can be derived from a single waist mounted activity monitor. This information when translated into clinically relevant measures, not only reflects patients condition in a similar way as convention tools but also shows the continuous status of functional capacity. In this paper, various such clinically relevant measures which can be derived from acceleration and ECG signals are described.