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We present the design of a single-chip delta-sigma (DeltaSigma) modulation-based class-D amplifier for driving headphones in portable audio applications. The presented class-D amplifier generates output pulse signals using a single-bit fourth-order high-performance DeltaSigma modulator. To achieve a high signal-to-noise ratio and ensure system stability for a large input range, the locations of the modulator loop filter poles and zeros are optimized and thoroughly simulated. The test chip is fabricated using a standard 0.18-mum CMOS process. The active area of the chip is 1.6 mm2. It operates for the signal bandwidth from 20 Hz to 20 kHz. The measured total harmonic distortion plus noise at the 32-Omega load terminal is 0.022% from a single 3-V power supply.