By Topic

Large-Scale, High-Resolution Data Acquisition System for Extracellular Recording of Electrophysiological Activity

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

8 Author(s)
Kilian Imfeld* ; Inst. of Microtechnol., Univ. of Neuchatel, Neuchatel ; Simon Neukom ; Alessandro Maccione ; Yannick Bornat
more authors

A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 mum on an active area of 2.67 mm times 2.67 mm, and in the zooming mode, temporal resolutions down to 8 mus on 64 randomly selected electrodes. The low-noise performances of the integrated amplifier (11 muVrms) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data.

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:55 ,  Issue: 8 )