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A new adaptive equalizer based on gene SPILL (Simulated Prokaryote Interchange of aLLeles) algorithm is proposed. The gene SPILL algorithm is based on prokaryote genetic exchange pattern. This algorithm has been used to optimize the weights of the equalizer. The performance of the proposed equalizer has been evaluated and compared with its LMS based counter part. It is observed that the new equalizer offers better performance in terms of rate of convergence.