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A novel low-cost filter design for common-mode noise suppression in high-speed differential signals is proposed. It is realized by periodically etching the dumbbell-shape defected ground structure (DGS) to perturb the return current of the common-mode noise. A transmission-line model for the proposed structure is also developed with good agreement to the full-wave simulation and measurement result. It is found that over 20 dB of common-mode noise suppression can be achieved over a wide frequency ranges from 3.3 to 5.7 GHz with 3 cascaded DGS cells, while the differential signals still keep good signal integrity in eye-pattern observation.