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The authors propose a new advanced spectrum management (ASM) methodology for wideband code division multiple access systems based on the concept of coupling matrix, which is able to capture inter-cell interactions. The proposed methodology takes into account the fact that each cell can be associated to more than one carrier and aims at liberating some carriers in large geographical zones, so that they could eventually be used by, for example, secondary cognitive radio users that exploit the flexible frequency allocation and opportunistic spectrum access. Simulation results show that the proposed methodology increases spectrum efficiency while guaranteeing the requested QoS levels. Moreover, a new metric has been introduced to reflect the capability of the ASM methodology to liberate some carriers in large geographic zones. This metric has been used to compare the different approaches presented here.