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In preparation for the startup of the LHC at CERN, the ATLAS collaboration is performing computing challenges of increasing complexity and scale. Monte Carlo production is ongoing with some 10,000 concurrent jobs worldwide, including at Canadian collaborating institutes. TRIUMF hosts one of the 10 ATLAS 'Tier-1' data and computing centres, where 270 TB of data per year will be transferred, by high performance dedicated networks, processed and redistributed for analysis. We discuss recent large scale tests of all aspects of middleware, hardware infrastructure and procedures to support the 24 times 7 operation of the Tier-1 centre, required for LHC running.