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In the paper a soft sensor design strategy for an industrial process, via neural NMA model, is described. A general design strategy, based on the automatic selection of regressors of a NMA model is proposed. It is based on the minimization of the cost function of a Gath Geva clustering algorithm. The obtained soft sensor will be implemented in a refinery in order to replace the measurement device during maintenance to guarantee continuity in the monitoring and control of the plant.