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A grid technology is one of key issues for healthcare services provided in collaborative environments. In this paper, a SLA-adaptive workflow integrated grid resource management system for supporting collaborative heart disease simulator application in Physio-Grid service is proposed. At first, we propose the system architecture and framework that integrates workflow function into policy quorum based resource management (PQRM) system, one of existing grid resource management systems, for collaborative healthcare services. In addition, we derived the cost-adaptive policy adjustment scheme to adjust a gap between conditions and actions of workflow management and resource management policies for the proposed system. Based on this adjustment scheme, an appropriate policy can be selected according to QoS constraints of collaborated healthcare applications given by SLA negotiated with users. Finally, we evaluate proposed system using a collaborative heart disease simulation service and show the proposed system outperforms a general grid management system throughout performance comparisons under different types of SLA.