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This paper studies two MIMO architectures for single-carrier CDMA system employing block spreading, namely Layered Space-Time Block Spread CDMA (LST BS-CDMA) and Space-Time Coded Block Spread CDMA (STC BS-CDMA). It is shown that under low mobility conditions, the proposed systems are virtually free from Multiple User Interference (MUI) and the block processing technique used leads to considerable reduction in the overall processing complexity. Extensive simulation was performed to study the impact of the spreading factor and Doppler frequency on the proposed systems. A new parameter called channel coherence ratio (CCR) is introduced as a key parameter in determining the performance of MIMO BS-CDMA.