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Detection of multiple pathways in the spinal cord white matter using q-ball imaging

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6 Author(s)
J. Cohen-Adad ; INSERM U678, Université Pierre et Marie Curie (Paris VI), CHU Pitié-Salpêtrière, France ; M. Descoteaux ; S. Rossignol ; R. D. Hoge
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High angular resolution MRI such as q-ball imaging (QBI) allows to recover complex white matter architecture. We applied this technique to an ex vivo spinal cord of one cat using a 3T scanner, 100 directions and b-values varying from 1000 to 3000 s/mm2. As a result, QBI can retrieve crossing fibre information, where the diffusion tensor imaging approach is constrained to a single diffusion direction. To our knowledge, this is the first study demonstrating the benefits of QBI in observing longitudinal, commissural and dorso-ventral fibres in the spinal cord. It is a first step towards in vivo characterization of the healthy and injured spinal cord using high angular resolution diffusion imaging (HARDI) and QBI.

Published in:

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

Date of Conference:

14-17 May 2008