By Topic

A new evaluation of the brain parenchymal fraction: Application in multiple sclerosis longitudinal studies

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Souplet, J.C. ; Asclepios team, INRIA, Sophia-Antipolis ; Lebrun, C. ; Ayache, N. ; Malandain, G.

In multiple sclerosis (MS) research, burden of disease and treatments efficacy are mainly evaluated with lesion load and atrophy. The former being poorly correlated with patient's handicap, it is of interest to evaluate accurately the latter. A lot of methods to measure the brain atrophy are available in the literature. The brain parenchymal fraction (BPF) is one of these methods. It needs a precise segmentation of the brain and of the cerebro-spinal fluid. However, artefacts like partial volume effects (PVE) can impair this classification. According to some articles, the BPF may also be less precise in longitudinal studies. To address these points, this article proposes a new method to evaluate the BPF which is based on an expectation-minimization framework taking into consideration the PVE. Modifications of the workflow are also proposed to improve its reliability in longitudinal study. Experiments have been conducted on simulated pathological images that validate the different measures.

Published in:

Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on

Date of Conference:

14-17 May 2008