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This paper describes work currently underway aiming to develop a distributed collaborative infrastructure to support the national science, especially the biosafety research in China. The irresistible trend of e-Science indicates that in the future more and more scientific researches will be carried out through close cooperation among collaborators. Following this trend, we need an infrastructure to satisfy the needs among institutes located across China. In this paper, we analyze the requirements for creating and maintaining a coherent Grid-enabled application management framework in a distributed environment from domain experts' and administrators' perspectives. Under such framework, we further develop computational and instrumental tools with Grid technology. As Grid is evolving over recent years towards the use of service-oriented architecture, we propose a solution with designing and implementing featured services based on the real demand of the biosafety research. This scalable architecture allows it grow into a bigger and comprehensive system with large amount of resources to better support scientific research and education.