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Automatic Synthesis of Ethyl [18F]Fluoroacetate and its First PET Imaging

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4 Author(s)
Li-quan Sun ; Sch. of Life Sci. & Technol., Beijing Inst. of Technol., Beijing ; Mori, T. ; Kobayashi, M. ; Okazawa, H.

[18F]FDG has been the most widely used as the PET tracer for detecting brain and systemic tumors, however, [18F]FDG uptake in adjacent normal brain tissue is so strong that [18F]FDG-PET imaging could not give an effect for brain functional imaging. In order to develop new PET radiopharmaceuticals to complement [18F]FDG, a simple method for automatic synthesis of ethyl [18F]fluoroacetate which can be operated in a commercial synthesizer has been established. The simple preparation of ethyl [18F]fluoroacetate was accomplished in a short synthesis time of 24 min and with a reproducible radiochemical yield of 41.4 plusmn 10.2 %, (decay corrected), and high radiochemical purity more than 98%. The PET imagings of ethyl [18F]fluoroacetate and sodium [18F]fluoroacetate were obtained in marmoset brain. SUV of ethyl [18F]fluoroacetate in the brain was 1.6, which was about 2.6 times higher than that of sodium [18F]fluoroacetate. The present results showed that ethyl [18F]fluoroacetate should be an ideal tracer for brain PET imaging.

Published in:
Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on

Date of Conference: 16-18 May 2008

Page(s):
2537 - 2540
E-ISBN :
978-1-4244-1748-3
Print ISBN:
978-1-4244-1747-6
INSPEC Accession Number:
10049783
Conference Location :
Shanghai
Digital Object Identifier :
10.1109/ICBBE.2008.968
Product Type:
Conference Publications

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