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A new biomedical instrument is introduced to apply multiple surgical clips to patients' tissue or vessel. In the surgical process, the instrument jaw is placed around the tissue or other organ structure. When bring the handles of instrument together, the clip can close and secure the tissue or vessel to prevent them from bleeding. With the release of handles, next surgical clip is automatically loaded into the instrument jaw. This latest design shows several potential features to help surgeons' operational procedure if compared with current surgical clip instrument, including advanced mechanism proposed to eliminate the accident shooting out when surgical clip is loaded into jaws, strong structure designed to reduce the jaw twist that can damage tissues, enhanced supporting feature added to prevent accident jaw closure when extra side-load exerted, and etc. The instrument is analyzed by computer modeling and simulation to prove its feasible performance with good mechanical advantage.