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Systems engineering has been applied to the problems faced by DHS, including defending the homeland against a complex threat. An initiative currently underway by DHS S&T will use systems engineering to perform analysis against a scenario prior to the field experiment. The systems engineering analysis will help define the specific configuration, location, and Concept of Operations (CONOPs) of the system. Results from the experiment will be fed back into the systems engineering framework architecture in order to refine and tune the analysis. This will give the systems engineers a higher confidence in the analysis and recommendations in future experiments as the system is improved, new sensors are added, and the threat becomes more complex.