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Spatial subchannels in multiuser multiple-input multiple-output/orthogonal frequency-division multiplexing (MIMO/OFDM) systems are invested. With the goal of maximizing the overall system throughput, we derive the criterion of subcarrier allocation and introduce an adaptive resource allocation algorithm. Furthermore, a time-frequency blockwise loading design which may decrease the computational complexity is suggested. The simulation results show that the algorithm can achieve good performance and high transmission rate efficiently.