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Estimating human age automatically via facial image analysis has lots of potential real-world applications, such as human computer interaction and multimedia communication. However, it is still a challenging problem for the existing computer vision systems to automatically and effectively estimate human ages. The aging process is determined by not only the person's gene, but also many external factors, such as health, living style, living location, and weather conditions. Males and females may also age differently. The current age estimation performance is still not good enough for practical use and more effort has to be put into this research direction. In this paper, we introduce the age manifold learning scheme for extracting face aging features and design a locally adjusted robust regressor for learning and prediction of human ages. The novel approach improves the age estimation accuracy significantly over all previous methods. The merit of the proposed approaches for image-based age estimation is shown by extensive experiments on a large internal age database and the public available FG-NET database.