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A DNA Sensor for Sequencing and Mismatches Based on Electron Transport Through Watson–Crick and Non-Watson–Crick Base Pairs

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2 Author(s)
Luis A. Jauregui ; Dept. of Chem. Eng., Texas A&M Univ., College Station, TX ; Jorge M. Seminario

A combined density functional theory and Green's function procedure is used to calculate the electrical characteristics of Watson-Crick and non-Watson-Crick base pairs; calculations are performed to determine: the molecular orbitals that participate in the electron-transfer process, junction current-voltage characteristics, density of states, transmission function, and molecular electrostatic potentials. The distinct current-voltage features of base pairs can be used for detecting and sequencing DNA, as well as for detecting DNA base-pair mismatches by passing the double strand through two perpendicular metallic electrodes to the DNA, or by scanning the double strand with conducting probes. We find in the range from 1 to 1 V for the Watson-Crick pairs that the CG is a better electron conductor than the AT and, on the other hand, the best and worst conductors are the non-Watson-Crick mismatches CT and AA, respectively.

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IEEE Sensors Journal  (Volume:8 ,  Issue: 6 )