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Concept studies for deep space missions are typically time-consuming and costly, given the variety of missions and uniqueness of each design. Yet, in an increasingly cost-constrained environment, it is critical to identify the most scientifically valuable and cost-effective designs early in the design process. Modeling is an integral part in helping to identify the most desirable design option. While some spacecraft design models currently exist for Earth-orbiting spacecraft, there has been less success with deep space missions. Instead, these missions require a modified design and modeling approach to enable the same construction of a comprehensive, yet credible, mission tradespace. This paper presents an approach for efficiently constructing such a mission tradespace. In addition to a proposed design and modeling approach, three case study missions are presented including a solar orbiter, a Europa orbiter, and a near-Earth asteroid (NEA) sample return mission.