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Resonant Recognition Model for Prediction of 'Lead-In Regions' in Proteins

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3 Author(s)
Jaiswal, M. ; Dept. of Biotechnol., IIT Guwahati, Guwahati ; Prasanna, S. ; Rangan, L.

In this study, the resonant recognition model (RRM), was developed to locate the so called 'lead-in regions' or residues that contribute to the creation of the environment that enables proteins to perform their complex functions. The RRM is a physical and mathematical model and provides a significant correlation between spectra of numerical presentation of amino acids and their biological activity. We developed a preliminary model for this purpose and applied it on two well characterized classes of enzymes viz., human proteases and kinases. The results obtained (positions of 'lead-in residues' in the primary structure of the proteins) were used in association with the 3D-structure data of the proteins for the purpose of predicting the catalytic residue of the enzyme.

Published in:

Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007

Date of Conference:

11-13 Oct. 2007