By Topic

Ventricular response during atrial fibrillation: Evaluation of exercise and flecainide effects

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Corino, V.D.A. ; Dipt. di Bioingegneria, Politec. di Milano, Milan ; Mainardi, L.T. ; Husser, D. ; Klein, H.U.
more authors

Ventricular response (VR) during atrial fibrillation (AF) is a complex process, which is modulated by the autonomic nervous system (ANS). The purpose of this study was to characterize VR to both exercise as ANS stimulus and flecainide which is also supposed to have effects on the ANS. RR series were analyzed by means of time domain parameters and non-linear methods. In 15 patients (10 male, aged 55 plusmn 13 years) with persistent AF (mean AF duration 13 plusmn24 months), time domain parameters and indexes assessing the predictability of the time series, (regularity index, approximate entropy and an index for linear predictability) were evaluated. VR during exercise resulted modulated by adrenergic stimulation. Flecainide exhibited vagolytic activity especially during exercise. Thus, monitoring of exercise- induced and antiarrhythmic drug effects on ANS is possible with parameters derived from time domain and non-linear analysis.

Published in:

Computers in Cardiology, 2006

Date of Conference:

17-20 Sept. 2006