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In this paper, an efficient resource management scheme applied to heterogeneous services scenario in multiple- input and multiple-output/orthogonal frequency division multiplexing (MIMO/OFDM) system is proposed. The design of the scheme is to maximize the system throughput while guaranteeing QoS requirements for users. At medium access control (MAC) layer, an urgency-factor based scheduler is designed to utilize the properties of packet data system. An efficient resource allocation algorithm at physical (PHY) layer, which jointly adapt subcarrier allocation, power distribution and bit loading according to instantaneous channel conditions, is proposed. The scheduler and the resource allocator are tightly coupled together through the cross-layer approach. The simulation results show that the proposed scheme improves the system throughput and makes use of resource more efficiently, while guaranteeing QoS for heterogeneous services.