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Robust Predictive Control Strategy Applied for Propofol Dosing Using BIS as a Controlled Variable During Anesthesia

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6 Author(s)
Ionescu, C.M. ; Dept. of Electr. Energy, Ghent Univ., Ghent ; De Keyser, R. ; Torrico, B.C. ; De Smet, T.
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This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.

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Biomedical Engineering, IEEE Transactions on  (Volume:55 ,  Issue: 9 )