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As a response to the challenge of providing high-quality healthcare services with reasonable costs while the elderly population and the associated chronic diseases increase, SAPHIRE architecture provides an intelligent healthcare monitoring architecture. The monitoring of patients is achieved through a clinical decision support system based on clinical guidelines. SAPHIRE provides the necessary interoperability layers to access the patient's vital signs from wireless medical sensors and the electronic healthcare records of the patient in order to exploit them in the decision process seamlessly. This architecture is presented through two pilot applications: one for the bedside monitoring of cardiac patients at hospitals, and the other for homecare monitoring of the cardiac patients rehabilitated after a revascularisation therapy.