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The paper presents a generalized transmission line model able to describe the high-frequency mixed-mode propagation along electrical interconnects. The model is derived from a full-wave formulation and extends the validity of the standard transmission line (TL) model to frequency ranges where the propagation is no longer of transmission electron microscopy (TEM)-type. This generalized TL model describes the high-frequency differential and common mode propagation and the mode conversion. Within its validity limits, the proposed model provides solutions in good agreement with those obtained through full-wave models. Case studies are carried out to evaluate the high-frequency mode conversion in asymmetric interconnects.