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Sample-time error among the channels of a time-interleaved analog-to-digital converter (ADC) is the main reason for significant degradation of the effective resolution of the high-speed time-interleaved ADC. A calibration technique for sample-time mismatches has been proposed and implemented at a low level of complexity. The calibration method uses random data and is especially suitable for ADCs used in digital data communication systems. An 800-MS/s four-channel, time-interleaved ADC system has been implemented to evaluate the performance of the technique. The experimental results show that the spurious-free dynamic range of the ADC system is improved to 58.1 dB at 350 MHz. The ADC system achieves a signal-to-noise and distortion ratio of 59.6 dB at 5 MHz and 50.1 dB at 350 MHz after calibration.