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Obtaining training data for land cover classification using remotely sensed data is time consuming and expensive especially for relatively inaccessible locations. Therefore, designing classifiers that use as few labeled data points as possible is highly desirable. Existing approaches typically make use of small-sample techniques and semisupervision to deal with the lack of labeled data. In this paper, we propose an active learning technique that efficiently updates existing classifiers by using fewer labeled data points than semisupervised methods. Further, unlike semisupervised methods, our proposed technique is well suited for learning or adapting classifiers when there is substantial change in the spectral signatures between labeled and unlabeled data. Thus, our active learning approach is also useful for classifying a series of spatially/temporally related images, wherein the spectral signatures vary across the images. Our interleaved semisupervised active learning method was tested on both single and spatially/temporally related hyperspectral data sets. We present empirical results that establish the superior performance of our proposed approach versus other active learning and semisupervised methods.