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Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology

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5 Author(s)
Han Jae-Joon ; Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN ; Plawecki, M.H. ; Doerschuk, P.C. ; Ramchandani, V.A.
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Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained

Published in:

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Date of Conference:

Aug. 30 2006-Sept. 3 2006