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Engineered Cardiac Tissues for in vitro Assessment of Contractile Function and Repair Mechanisms

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7 Author(s)
Do Eun Kim ; Dept. of Biomed. Eng., Columbia Univ., New York, NY ; Eun Jung Lee ; Martens, T.P. ; Kara, R.
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For efficiently assessing the potential for grafted cells to repair infarcted myocardium, a simplified surrogate heart muscle system would offer numerous advantages. Using neonatal rat cardiac myocytes in a collagen matrix, we created thin cylindrical engineered cardiac tissues (ECTs) that exhibit essential aspects of physiologic cardiac muscle function. Furthermore, a novel cryo-injured ECT model of myocardial infarction offers the potential for the longitudinal study of mechanisms of cell-based cardiac repair in vitro

Published in:

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Date of Conference:

Aug. 30 2006-Sept. 3 2006

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