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Optical phase conjugation (OPC) is a promising technique to compensate the nonlinear impairment in optical fiber communications. However, the compensation for nonlinearity by use of OPC is limited by the asymmetry of signal power. Thus, the optimization of a link taking advantage of OPC is demanded. In this letter, an analytical model is proposed to optimize the design of self-phase-modulation (SPM)-limited systems in which the nonlinearity is compensated by OPC. Using the model, the optimal location of the phase conjugator can be evaluated, and an analytical expression of optimal net residual dispersion is obtained. Moreover, the SPM-compensation efficiency of OPC can be estimated conveniently.