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In this paper, we presented the wireless sensor networks (WSN) to observe the human physiological signals by ZigBee, which is provided with lower power consumption, small volume, high expansion, stylization and two-way transmission, etc. ZigBee is generally used for home care, digital home control, industrial and security control. This paper developed a suite of home care sensor network system by ZigBee's characteristic, which is embedded three sensors (temperature sensor, humid sensor, and light sensor). It is attached to other sensors, such as the biosensor for observe heart rate and blood pressure. We implemented Panasonic EW3035 blood pressure monitor to measure heart rate and blood pressure. The biosensor transmits measured signals via ZigBee, and then sends to the remote wireless monitor for acquiring the observed human physiological signals. The remote wireless monitor is constructed of ZigBee and personal computer (PC). The measured signals send to the PC, which can be data collection, analyzing and statistic. When the measured signals over the standard value, the personal computer sends Global System for Mobile Communication (GSM) short message to the manager. The manager can use the PC or personal digital assistant (PDA) to observe the observed human physiological signals in the remote place.