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This paper presents the application of self-sensing actuation (SSA) to facilitate the implementation of piezoelectric actuator in an intelligent mechatronic system. SSA is a technique to employ smart materials, such as piezoelectric materials, simultaneously as a sensor and an actuator; thereby increasing the level of integration of the system. The piezoelectric actuator is equipped with an exclusive adaptive controller amidst its nonlinearities and system's disturbance. The application area to be discussed is a microdispensing system, which is an example of a micromanufacturing process, combining a fluidic system and a positioning system.