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In this paper, we propose an original detection scheme for high rate short-range impulse radio ultra-wideband systems. The proposed receiver relies on both the introduction of the cyclic prefix at the transmitter and the use of a frequency domain multiuser detector at the receiver. Zero forcing (ZF) and minimum mean square error (MMSE) detection strategies have been investigated and compared with the classical RAKE, considering a scenario where several mobile terminals communicate with a base station in an indoor environment characterized by severe multipath propagation. The results show that the MMSE receiver achieves the best performance, irrespective of the number of active terminals, both in the uplink and in the downlink communications. Hence, the proposed approach is well suited in indoor wireless environments where the multipath propagation tends to increase the effects of both the inter-path and the inter-user interference.