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The hospital activities display all of the characteristics of a very complex sociotechnic organisation. Consequently, the design of Computerized Physician Order Entry (CPOE) softwares which support this type of activity is very difficult. The Study of the procedure of these projects shows communication information problems between project partners. This article proposes the principles of an approach, based on Software Engineering (SE) and Human-Computer Interaction (HCI) methods and models, allowing improving the transmission of information during design or re-engineering projects within complex organisation.