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Dual drug delivery device for chronic pain management using micromachined elastic metal structures and silicon microvalves

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4 Author(s)
Evans, A.T. ; Univ. of Michigan, Ann Arbor ; Park, J.M. ; Chiravuri, S. ; Gianchandani, Y.B.

This paper describes a dual-chamber drug delivery microsystem that provides regulated flow from two spring- pressurized balloon reservoirs using independent microvalves. A preliminary prototype has been constructed with the primary components. Micromachined bulk metal springs (Co-Ni-Cr alloy), with an in-plane spring constant exceeding 300 N/m, are used in conjunction with 18.8 mL reservoirs, and provide 15 kPA pressure when the balloons are fully inflated. A piezoresistive pressure sensor that is embedded in the microvalves monitors reservoir pressure with a sensitivity of 250 ppm/kPa, and is used to regulate bolus delivery. Two control plans for the valve and their respective limitations are presented. In a demonstration of regulated bolus delivery, 1.5 mL bolus doses are delivered at different rates.

Published in:

Micro Electro Mechanical Systems, 2008. MEMS 2008. IEEE 21st International Conference on

Date of Conference:

13-17 Jan. 2008