Finger-top total protein analysis system based on new biochemical IC chip

This paper presents a novel miniaturized chemical system for electrophoretic separation and collection of protein. The system was made into a module of “Bio-chemical IC”. “Bio-chemical IC” is a finger top size device for diverse chemical experiment. By using the new module, the whole micro-scale protein analysis system can be miniaturized into a finger-top size. The module has realized real-time monitoring of protein electrophoresis, and on-demand collection of target proteins during the electrophoresis. Separation of mixture of five different proteins and collection of the target protein were successfully demonstrated with this module. Moreover, we have succeeded in collecting a part of proteins from PC12 cells.