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Most asynchronous processor ISA (instruction set architecture) implementations are based on only one type of asynchronous design style. The ISA is dependent on the type of asynchronous design style chosen and is optimized to support a particular set of applications. Design reuse is typically difficult to realize in these cases. In this paper, we share some of the preliminary finds on configuring an ISA based on application profile-driven select of 2 types of underlying asynchronous design styles. The target embedded processor having such an ISA does not run an operating system and can be used both as a complement and alternative to software-defined radio solutions.