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The information diffusion protocol represents a prototype for transferring the information from the source to its destination. The chemical information diffusion (CID) protocol is a type of information diffusion method used in the autonomic networks. In this protocol, network resembles a glass of the water and nodes work as molecules of it. The goal of this research is to apply a special novel algorithm on CID protocol to improve the performance of it. This paper describes a special non-uniform algorithm for improving the performance of the original CID protocol. This paper also briefly describes some other spreading algorithms and compares the behavior of them and proposed non-uniform algorithm on the original CID protocol. In addition it shows the reason and the power of improving the CID protocol when it uses proposed non-uniform algorithm.